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Despite the more than a century-long history of the use of analgesics, studies of various new classes of drugs with analgesic activity continue in the pharmacological era – these are drugs that act on different pathophysiological stages of the formation of pain (nociceptive system), and medications with action against structures are also being studied suppressing …

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Of the entire class of painkillers, opioid analgesics are the strongest, while taking into account the current perception of pain as a multidisciplinary problem. The appointment of an opioid analgesic does not always guarantee adequate treatment of the pain syndrome itself with a reflex muscular response or with the myofascial syndrome (muscle-tonic syndrome). Altered motor …

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Further development of the pharmacological market of painkillers went by leaps and bounds, encountering only those or other complications inherent in each class of drugs. So, myelotoxicity blocked the development of pyrazolone derivatives. The use of metamizole sodium was limited due to possible haematological problems, the phenylbutazone drug. Which arose in 1949, also received a …

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Currently, studies on painkillers are conducted to obtain data on their effectiveness and safety, regarding relatively new drugs, and comparison in efficiency with the existing “gold standards”. If we consider the frequency of occurrence of an RCT request (randomized clinical trials) regarding the use of analgesics at pubmed.com, the maximum results will be obtained in …

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The treatment of dysfunctional pain can also include the appointment of anticonvulsants and antidepressants, but, besides, it must be carried out with the participation of specialists in related specialities. Specialists in charge of the field of pain (ENT specialist, orthodontist for facial pain, for example), and a psychiatrist, whose participation is necessary to evaluate affective …

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Chronic pain lasts for a long time. A person who has been experiencing pain for a long time behaves differently than one for whom pain is a new sensation. People who suffer misery for a long time may not moan, do not show motor anxiety, their heart rate and respiration may be healthy, but the …

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Pain can complicate the course of other ailments or provoke the appearance of new ones. For example, daily back pain by 113% increases the risk of cardiovascular complications. In addition to relieving patients from pain, doctors have another task – to improve the quality of life of patients. As you know, in chronic pain, many …

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Now medicine pays excellent attention to the problem of chronic (lasting more than six months) pain syndrome. In the new international classification of diseases (ICD-11), chronic pain is designated as an independent disease. Every fifth inhabitant of Europe suffers from it, and globally 20% of the world world’s population. A third of patients experience pain …

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Another important classification, the use of which in clinical practice allows shortening the patient’s recovery period, is the division of pain according to damage mechanisms (the so-called pathophysiological classification) into nociceptive, neuropathic and dysfunctional. Nociceptive pain is usually clearly localized because it is caused by damage to specific structures. A connection with movement and activity …

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Local inflammation, peripheral and central sensitization are standard adaptive mechanisms necessary to repair the damage. At the same time, it is these changes that are triggered or changed in the process of the formation of chronic pain. Sometimes, a face scale (FPS-R) (see Figure 2 ) or the so-called face scale is used to assess …

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